"This is a truly remarkable breakthrough," he said in a statement. Robert Montgomery, who led that experiment at NYU Langone Health. The Maryland transplant takes their experiment to the next level, said Dr. Doctors temporarily attached a pig's kidney to a deceased human body and watched it begin to work. Just last September, researchers in New York performed an experiment suggesting these kinds of pigs might offer promise for animal-to-human transplants. The Food and Drug Administration, which oversees xenotransplantation experiments, allowed the surgery under what's called a "compassionate use" emergency authorization, available when a patient with a life-threatening condition has no other options. Still, Klassen cautioned that it's only a first tentative step into exploring whether this time around, xenotransplantation might finally work. David Klassen, UNOS' chief medical officer, said of the Maryland transplant. ![]() "I think you can characterize it as a watershed event," Dr. The difference this time: The Maryland surgeons used a heart from a pig that had undergone gene-editing to remove a sugar in its cells that's responsible for that hyper-fast organ rejection. Notably, in 1984, Baby Fae, a dying infant, lived 21 days with a baboon heart. Muhammad Mohiuddin, scientific director of the university's animal-to-human transplant program.īut prior attempts at such transplants - or xenotransplantation - have failed, largely because patients' bodies rapidly rejected the animal organ. "If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Last year, there were just over 3,800 heart transplants in the U.S., a record number, according to the United Network for Organ Sharing, which oversees the nation's transplant system. There's a huge shortage of human organs donated for transplant, driving scientists to try to figure out how to use animal organs instead. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the surgery, according to a statement provided by the University of Maryland School of Medicine. ![]() "It was either die or do this transplant. The patient, David Bennett, 57, knew there was no guarantee the experiment would work but he was dying, ineligible for a human heart transplant and had no other option, his son told The Associated Press. Doctors at the University of Maryland Medical Center say the transplant showed that a heart from a genetically modified animal can function in the human body without immediate rejection. While it's too soon to know if the operation really will work, it marks a step in the decades-long quest to one day use animal organs for life-saving transplants. In a medical first, doctors transplanted a pig heart into a patient in a last-ditch effort to save his life and a Maryland hospital said Monday that he's doing well three days after the highly experimental surgery. Mark Teske/University of Maryland School of Medicine via AP ![]() On Monday, the hospital said that he's doing well three days after the highly experimental surgery. In this photo provided by the University of Maryland School of Medicine, members of the surgical team perform the transplant of a pig heart into patient David Bennett in Baltimore on Friday.
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![]() ![]() To achieve the most flavorsome profile, it’s a good idea to use high-quality beans. In short, it’s a tasty middle ground that many coffee drinkers enjoy. There’s a higher milk ratio, so it’s generally weaker than a regular espresso but slightly stronger than a cappuccino. Since macchiato is made from espresso, you can expect a full-bodied flavor. The cafe pingado is a strong espresso drink with a drop of steamed milk. It’s believed that the macchiato was invented in the early 1980s by Italian baristas who needed to distinguish a plain espresso from one containing a splash of milk.Īn interesting fact is that a similar coffee beverage is made in Portugal. The term “macchiato” translates from Italian as “stained” or “marked.” It refers to staining or marking the coffee with a dash of milk. ![]() And, since it’s served in a smaller glass or cup, you can expect a robust beverage. Since a macchiato is made by just adding a small amount of milk, it has a much stronger flavor than regular coffee drinks. What Makes a Macchiato Different From Regular Coffee? Macchiatos are generally the preferred drink of people who want a coffee that lies between the harsh espresso and the weaker cappuccino. This allows the espresso to shine through the milk. It’s usually topped with a small amount of steamed milk and foam. How is a macchiato different from an Americano?Įssentially, a macchiato is an espresso coffee drink.Is a caramel macchiato better hot or cold?.How is a latte different from a macchiato?.Which is stronger, a macchiato or cappuccino?.How to Make a Caramel Macchiato at Home.Step 4: Pour the Steamed Milk into Espresso.Easy Guide to Making a Macchiato at Home.What Makes a Macchiato Different From Regular Coffee?. Uses & devicesĪutoCAD can be used on any Windows device and, surprisingly, Mac devices. Section plane creates a live cross-section, making the inner details of your model viewable for extra intricate depth. Navigating within the 3D interface allows you to view your object from all angles and manipulate your depth of view. Unless you are an experienced user, switching over to 3D can feel like starting from square one all over again. The interface then plays against you as navigating in a 3D space can cause headaches. While you can convert 2D images to 3D and vice versa, the complexity becomes noticeable when you create a new 3D model. Revision clouds can be used to show where objects or elements have been revised, making communication easier between team members, but more importantly, giving a clear framework for internal project documentation.ģD falls behind significantly with ease of use. Detailed elevation drawings become far easier to create and view, including drafting. With these tools, users can automatically create dimensions that move automatically when the object is moved. More experienced users, or experimenters, can allow macros to create shortcuts to help them speed up tool access.įor 2D, users can leverage AutoCAD to quickly draft detailed designs with greater accuracy as there is no need to use drawing instruments in a digital landscape. Instead, its functionality truly shines when used to create 2D designs and in-depth blueprints.ĭespite the complexity associated with CAD software as a whole, AutoCAD features an easy-to-use interface, enabling users to quickly find the tools they need through large icons and a clutter-free layout. ![]() It simply wasn't built to be used as a dedicated 3D model creation tool. While 3D model creation is a possibility, its limitations quickly become apparent and, in some cases, frustrating. Undoubtedly, AutoCAD works best when creating detailed and accurate 2D models. However, if you're looking for something that'll allow you to create complex 3D models, then you may be disappointed. If you're looking for CAD software that provides 2D & 3D creation opportunities, then look no further. If you're looking for CAD software that enables you to focus solely on engineering or construction, you'll gain significant use from AutoCAD. ![]() Users can use many specialized toolsets and complementary programs that focus on specific disciplines rather than doubling down on complete coverage. Where AutoCAD lacks in complexity, it makes up for it with versatility. However, more experienced users might find AutoCAD lacking in extensive use and be less viable as an option for larger, more complex projects. ![]() AutoCAD provides excellent functionality for users looking to experience CAD software and begin learning its implementation. It’s more commonly used than -r and is the recommended flag to use. This flag syncs recursively and preserves symbolic links, special and device files, modification times, groups, owners, and permissions. To sync the contents of dir1 to dir2 on the same system, you will run rsync and use the -r flag, which stands for “recursive” and is necessary for directory syncing:Īnother option is to use the -a flag, which is a combination flag and stands for “archive”. You also have an empty directory called dir2. Outputfile1 file18 file27 file36 file45 file54 file63 file72 file81 file90įile10 file19 file28 file37 file46 file55 file64 file73 file82 file91įile100 file2 file29 file38 file47 file56 file65 file74 file83 file92įile11 file20 file3 file39 file48 file57 file66 file75 file84 file93įile12 file21 file30 file4 file49 file58 file67 file76 file85 file94įile13 file22 file31 file40 file5 file59 file68 file77 file86 file95įile14 file23 file32 file41 file50 file6 file69 file78 file87 file96įile15 file24 file33 file42 file51 file60 file7 file79 file88 file97įile16 file25 file34 file43 file52 file61 file70 file8 file89 file98įile17 file26 file35 file44 file53 file62 file71 file80 file9 file99 There’s now a directory called dir1 with 100 empty files in it. The syntax for rsync operates similar to other tools, such as ssh, scp, and cp.įirst, change into your home directory by running the following command: Due to its ubiquity on Linux and Unix-like systems and its popularity as a tool for system scripts, it’s included on most Linux distributions by default. Rsync is a very flexible network-enabled syncing tool. This guide was validated on machines running Ubuntu 20.04, although it should generally work with any computers running a Linux-based operating system that have rsync installed. Then, copy each server’s public key to the other server’s authorized_keys file as outlined in Step 2 of that guide. Regardless of what types of machines you use to follow this tutorial, you will need to have created SSH keys on both of them. To set up these servers, follow our Initial Server Setup Guide. If you plan to follow this guide using servers, it would be prudent to set them up with administrative users and to configure a firewall on each of them. These two machines could be virtual private servers, virtual machines, containers, or personal computers as long as they’ve been properly configured. In order to practice using rsync to sync files between a local and remote system, you will need two machines to act as your local computer and your remote machine, respectively. In this tutorial, we’ll define Rsync, review the syntax when using rsync, explain how to use Rsync to sync with a remote system, and other options available to you. It uses an algorithm to minimize the amount of data copied by only moving the portions of files that have changed. Unison is free full source code is available under the GNU Public License.Rsync, which stands for remote sync, is a remote and local file synchronization tool.Unison has a clear and precise specification.It is careful to leave the replicas and its own private structures in a sensible state at all times, even in case of abnormal termination or communication failures. Transfers of small updates to large files are optimized using a compression protocol similar to rsync. It is careful with network bandwidth, and runs well over slow links such as PPP connections. Unison works between any pair of machines connected to the internet, communicating over either a direct socket link or tunneling over an encrypted ssh connection.Unlike a distributed filesystem, Unison is a user-level program: there is no need to modify the kernel or to have superuser privileges on either host.Conflicting updates are detected and displayed. Updates that do not conflict are propagated automatically. Unlike simple mirroring or backup utilities, Unison can deal with updates to both replicas of a distributed directory structure.Moreover, Unison works across platforms, allowing you to synchronize a Windows laptop with a Unix server, for example. Unison runs on both Windows and many flavors of Unix (Solaris, Linux, OS X, etc.) systems.However, there are several points where it differs: Unison shares a number of features with tools such as configuration management packages ( CVS, PRCS, Subversion, BitKeeper, etc.), distributed filesystems ( Coda, etc.), uni-directional mirroring utilities ( rsync, etc.), and other synchronizers ( Intellisync, Reconcile, etc). ![]() ![]() It allows two replicas of a collection of files and directories to be stored on different hosts (or different disks on the same host), modified separately, and then brought up to date by propagating the changes in each replica to the other. Unison is a file-synchronization tool for OSX, Unix, and Windows. Note: The Unison project is now hosted on GitHub (here's a link). It contains 95% of the functionality that most people need to create a document.Like code, it’s in plain-text so is usable within an IDE and easy to copy/paste chunks of code into documentation. It appeals to techies -Markdown’s principle users - who want to use vim or emacs to write up documentation and notes (or say they do, anyways).The simple number of formatting rules is easily pulled into any publishing system and styled as needed.md docs are lightweight and portable across platforms. It separates the design of a document from its content, allowing writers to focus on what they’re writing.Markdown definitely has some benefits, otherwise people wouldn't use it. Why Markdown Sucks (by the creator of Erlang, RIP).Why You Should and Should Not Use Markdown.But I'm definitely not alone in my dislike of the format: If you somehow really like it, or are so used to it by now, you might be tempted to think I'm the oddball. But given the widespread use of Markdown, it might seem strange that I have such aversion to it. The left is somehow better than the right. Why is Markdown so popular? Notable's Markdown Editor. The Setup - interview about the tools I use.Pistol Slut, collision detection, AI, falling in love.Isla: a programming language for children.An intuitive introduction to algorithmic efficiency.A practical introduction to functional programming.Recorded on my phone in my kitchen in Berlin. 10997 - My latest record on Apple Music and Spotify.Little Lisp - A Lisp interpreter in JavaScript and an essay about how it works.I used what I learned building it to write an essay and talk on the innards of Git. Gitlet - Git implemented in 1000 lines of JavaScript.Coquette - A micro framework for JavaScript games. ![]() Featured in Kill Screen, PC Gamer and others. Throw crates, set off bombs, fire missiles, stab with your sword. Empty Black - A puzzle platform shooter.Guns, grenades, parallax scrolling, particle effects. Isla - A livecoding interface and programming language for young children.Includes a vm that lets the user run their program forwards or backwards. Code Lauren - An online IDE for beginners. ![]() On this website, we can type text in the visual editor on the left and generate its HTML code in the source editor on the right. To create this HTML document, we’ll use a website called HTML Editor. def topdf(title: str, markdownsource: str) -> bytes: htmlstyle MarkdownToPDF.css() htmlbody markdown2.markdown(markdownsource) html f .This is the Python 2 version of the package. Step 1: Create an HTML template with placeholdersįirst, we need to create an HTML document that we’ll use as a template later. Python wrapper for wkhtmltopdf utility to convert HTML to PDF using Webkit. Now let’s create a simple PDF with Python. In case you’re on Windows, you can download the installer here. Install python-pdfkit: pip install pdfkit (or pip3 for python3) Install wkhtmltopdf: Debian/Ubuntu: sudo apt-get install wkhtmltopdf macOS: brew install homebrew/cask. ![]() This is adapted version of ruby PDFKit library, so big thanks to them Installation. wkhtmltopdf.exe pdfkitwkhtmltopdfpythonwkhtmltopdf. Python 2 and 3 wrapper for wkhtmltopdf utility to convert HTML to PDF using Webkit. The steps to install it is up to your operating system: # macOS (you need to install brew first) brew install homebrew/cask/wkhtmltopdf # Ubuntu sudo apt-get install wkhtmltopdf pip pdfkit python 3.x pip install pdfkit Successfully installed pdfkit-0.6.1 2. Install pdfkit: You can install it with pip using the following command. pdfkit is one of the better approaches as, it renders HTML into PDF with various image formats, HTML forms, and other complex printable documents. To create a PDF file, we need to install the following libraries: pip install pdfkit pip install jinja2īefore we use the pdfkit library, we need to install wkhtmltopdf. There are many approaches for generating PDF in python. With this option, we can create basic and advanced PDFs in a few minutes! Install the libraries Refresh the page, check Medium ’s site status, or find something interesting to read. There are different ways to create a PDF file with Python, but I found using HTML templates the easiest one. Python 2 and 3 wrapper for wkhtmltopdf utility to convert HTML to PDF using Webkit. In this tutorial we will explore how to by Misha Sv Towards Data Science Write Sign up Sign In 500 Apologies, but something went wrong on our end. In order to continue in this tutorial we will need some HTML file to work with.Image by author How to Easily Create a PDF File with Python If you don’t have the Python library installed, please open “Command Prompt” (on Windows) and install it using the following code: In my case it is: C:\Program Files\wkhtmltopdf A nice feature of pdfkit is that you can use it to create PDF files from URLs. pdfkit was the first library I learned for creating PDF files. Remember the path to the directory where it will be installed. This post will cover two packages used to create PDF files with Python, including pdfkit and ReportLab. For Windows, you can find the latest version of wkhtmltopdf installer here. In order to use it in Python, we will also need the pdfkit library which is a wrapper for wkhtmltopdf utility.įirst, search for the wkhtmltopdf installer for your operating system. Wkhtmltopdf is an open source command line tool to render HTML files into PDF using the Qt WebKit rendering engine. To continue following this tutorial we will need: ![]() While it is a simple process, being able to automate it can be very useful for some HTML code testing as well as saving required webpages as PDF files. Wkhtmltopdf python wrapper to convert html to pdf using the webkit rendering engine and qt. Wkhtmltopdf conversion and all wkhtmltopdf options are available in Python from. There are several online tools that allow you to convert HTML files and webpages to PDF, and most of them are free. Python wrapper for wkhtmltopdf utility to convert HTML to PDF using Webkit. ![]() Below treelike subalpine fir and Englemann spruce are short and bent by the wind and severe weather. The tops of the tallest peaks reach above treeline (at 11,000 feet) and are topped with alpine meadows of low shrubs, sedges, wildflowers and cushion plants. ![]() The Rio Grande is one of the four longest rivers in the U.S. The Sangre de Cristo Mountains are the southernmost part of the Rocky Mountains and run north-south along the east side of the Rio Grande River. The tallest mountain is Wheeler Peak at 13,161 feet and found in the Carson National Forest. Northern New Mexico is covered in rugged, conifer-covered peaks of the southern Rocky Mountains. New Mexico has five National Forests and one National Grassland. The Rio Grande flows though the Chihuahuan Desert providing water for vegetation like cottonwood trees and catalpa (desert willow) along its banks. Surrounded by mountain ranges that block it from getting moisture, this dry region is still home to many plants, like creosotebush, mesquite, agave, ocotillo, barrel cacti and prickly pear. Biologists break them down into five ecosystems: alpine-conifer, desert and basin, juniper-scrub, plains-mesa, and riparian habitats.Ī portion of the Chihuahuan Desert is found in southern New Mexico. New Mexico has a wide array of natural communities including deserts, mesas, dry shrub and grassy plains, snow-capped mountains, forests, floodplains of the Rio Grande, woodlands, hilly scrublands, lava fields and volcanic plateaus. The 7 inch is fine for the purposes of pain relief and comfort, and if used correctly, will not disappoint. Pillow 29.99 When purchased online Sold and shipped by Evertone INC a Target Plus partner Okuna Outpost Inflatable Lumbar Support Pillow for Back, Triangle Wedge for Sleeping (17 x 14 x 7.5) Okuna Outpost 3 12.99 reg 19. For side sleepers, they can help support the neck and upper back if theyre properly aligned while sleeping. The zipper is average quality, but I would still not take my chances on putting this in a dryer on anything other than a low heat, and I plan on air drying my covers.When I buy this again, I may experiment with more thickness, but that is only because of how deep my club chair is, and I'd like to sit a bit more forward. Wedge pillows can benefit both if used properly. Deluxe Comfort Back and Body Contour Body Wedge - High Quality Memory Foam - Contours Perfectly - Provide Instant Relief and Comfort - Body Wedge. Here’s a step-by-step guide to using a wedge pillow after knee replacement. 39 Triangular Wedge Pillow Headboard Backrest Cushion Lumbar Support Pillow for Sofa Bed Day Bed ,Reading & Watching TV Pillow for Bedroom Dorm. I suffer from a consistent lower back pain, and I felt the pain ease immediately when I sat with this.The blue cover is a tad grainy, very reminiscent of hospital gown material, as other reviewers have stated. A wedge pillow can help to take the pressure off of your knees and help you to sleep more comfortably. Memory Foam Wedge Pillow 43.97 Amazon Though the wedge pillow is specifically designed to help with acid reflux, many of the reviews claim that the pillow also helps reduce snoring. ![]() ![]() ![]() There's enough give to very comfortably cushion my lower back, but not enough to easily allow me to sink into the chair. " Flipping the pillow around will cause massive discomfort, as the angle will be wrong for good posture.In a correct position, this foam holds very sturdily as I rest my full weight against it. The Imaginarium Fun Pillow Wedge is especially helpful for side sleepers with sharp pressure points or shoulder pain. I bought 2 of this product for myself, one for the bed, and one for sitting in my chair.My bed situation is unique, so I won't be covering or discussing that aspect of the pillow in my review, other than to say it's very firm, and works for my needs.As for a back support, I place this into my seat when sitting on either my sofa or my club chair (think of a club chair as like a sofa for one)First off, MAKE SURE THAT YOU PLACE THIS WITH THE "BOTTOM ANGLE" TO THE BACK OF THE SURFACE YOUR SITTING IN! When you first get this product, a information tag will be on the cover. /rebates/2fstore2fs2fpillow-wedges2f&. Report: Bill Clinton Set To Speak At Dem Convention If anyone things she wants BO to win then i have some magic pixy dust i want to sell you. I want a gas chamber that sprays pixy sticks instead of poison. I happen to love frogs : Even had a pixy frog as a pet until it died in a house fire. The ninth novel in the “Hollow” series has witch and bounty hunter Rachel Morgan traveling cross-county with an elf, pixy and vampire. Rodney Punt: A Turk in Italy Comes to Town in an Airstream Trailer Under James Conlon's sensitive and idiomatic leadership, and after some rough moments in the overture on opening night, the orchestra sparkled as it kept the action moving, sprinkling Rossinian pixy dust over the assembled and deftly changing gears from the frivolity later on for a few tender moments. ![]() Please remember it can take some time for your bank or credit card company to process and post the refund too."a kelpie is an imaginary water sprite, you know, and a pixy is a- a- why, a sort of make-believe fairy who lives in the water." If approved, you’ll be automatically refunded on your original payment method. We will notify you once we’ve received and inspected your return, and let you know if the refund was approved or not. The fastest way to ensure you get what you want is to return the item you have, and once the return is accepted, make a separate purchase for the new item. Please inspect your order upon reception and contact us immediately if the item is defective, damaged or if you receive the wrong item, so that we can evaluate the issue and make it right. You can always contact us for any return question at and issues Items sent back to us without first requesting a return will not be accepted. To start a return, you can contact us at If your return is accepted, we’ll send you a return shipping label, as well as instructions on how and where to send your package. You’ll also need the receipt or proof of purchase. To be eligible for a return, your item must be in the same condition that you received it, unworn or unused, with tags, and in its original packaging. We have a 30-day return policy, which means you have 30 days after receiving your item to request a return. A4 Prints are shipped with Royal Mail 1st Class. UK framed orders are normally shipped within two days on overnight 24hr tracked courier service. Framed prints and canvases arrive shrink wrapped and packaged securely in a weather resistant reinforced cardboard wrap to arrive safely at your door ready to hang on the wall. Larger prints are shipped rolled in robust tubes. Frames arrive ready to hang on the wall.Īll of our A4 prints are packed into a clear cellobag with a reinforced backing card and are shipped in sturdy envelope. Our framed art is glazed with crystal styrene for safety during transportation and in the home and to ensure longevity. Options of black grain, white grain or honey oak woods are available from sustainable sources. Most customers choose to have their print framed by our in-house team who manufacture all our frames by hand to order. The special formulation of the ink used combined with the great quality media means this print stays vibrant and vivid and prevents colour fade over time. Art print from an original by Pixy paper ©Īll of our prints are made to order and are either printed onto 240gsm matt coated heavyweight art paper or 260gsm canvas fabric using vibrant 12-colour ink digital processes. Available both as a framed print, print only or vibrant canvas art. ![]() The Fuckening Definition original Giclée fine art print. ![]() Senate Republican Leader Mitch McConnell released a statement applauding Trump's signing legislation but made no mention of the three items Trump claimed he was getting the Senate to do. 'As President, I have told Congress that I want far less wasteful spending and more money going to the American people in the form of $2,000 checks per adult and $600 per child,' he said in a statement announcing his signage Sunday evening. The president also included a demand that while Congress cuts out what he calls unnecessary spending, they also up direct checks for Americans from the $600 already included in the bill to $2,000. President Trump's public schedule notes he is working 'tirelessly' for the American people above he's seen on his golf course Trump spent Sunday afternoon on the phone with Mnuchin and House Republican Leader Kevin McCarthy, Axios reported, who persuaded him to sign the legislation.Īfter Trump announced he'd signed the bill, the House Appropriations Committee chairwoman called the president's proposed spending cuts dead on arrival.Ī spokesperson for New York Representative Nita Lowey, whose committee holds the power of the federal purse, said Trump's red-lined version of the sweeping aid and funding legislation is 'DOA.' Congress adjourns its session on January 3, giving lawmakers little time to act on any of the demands, and Trump himself is a lame duck president who will be out of office in 23 days. Trump's spending objects contain items his own administration requested in its budget proposal. Lawmakers have signaled none of these things will come to pass. Additionally, he claimed the Senate would increase the amount of the stimulus checks to $2,000, review repealing Section 230 that protects tech companies from blanket lawsuits, and probe vote fraud. In a statement accompanying the signing announcement, Trump said he was returning the bill to Congress with red lines through the spending he wanted cut. Trump's golf game on Monday comes after the president folded and signed the COVID relief/government funding bill he threatened to veto - getting nothing in return for the chaos he threatened. The president is not the only member of his administration on holiday - Vice President Mike Pence is in Vail, Colorado, and Treasury Secretary Steve Mnuchin is at a resort in Cabo, Mexico. The White House has not released details on what kind of meetings and calls the president had taken part of. His schedule has had the addendum on it since Thursday, his first full day in Florida where he's spending the holiday season with his family. His schedule includes many meetings and calls.' Trump's public schedule has no events listed but includes a note that: 'During the Holiday season, President Trump will continue to work tirelessly for the American People. |